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Small molecule screen manuscript Supplemental Figure S1 to S10 (proof).pdf (17.33 MB)
DATASET
Table S1 Summary of 61 top hits that passed the initial selection criteria (proof).xlsx (668.66 kB)
DATASET
Table S2 Cell death-imaging analysis of 32 core-set small molecules (proof).xlsx (28.2 kB)
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Table S3 Protection of WI-38 cells from the heavy metal CdCl2 by small molecules (proof).xlsx (20.49 kB)
DATASET
Table S4 Effects of small molecules on ATP level and DNA damage-associated markers (proof).xlsx (112.56 kB)
DATASET
Table S5A List of significant genes identified by RNA-seq for cells treated with Gr-4D (proof).xlsx (454.34 kB)
DATASET
Table S5B List of significant genes identified by microarray for cells treated with others (proof).xlsx (1.05 MB)
DATASET
Table S6 Summary of pathway analysis results for RNA-seq of cells treated with small molecules (proof).xlsx (46.57 kB)
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Table S7 Potential mTOR inhibition by certain small molecules (proof).xlsx (9.9 kB)
DATASET
Table S8 Effects of small molecules on C. elegansΓÇÖ lifespan and H2O2-resistance (proof).xlsx (19.62 kB)
DATASET
Table S9 Potential targets for small molecules (proof).xlsx (131.26 kB)
DOCUMENT
Small molecule screen manuscript Supplemental Text_proof.pdf (293.86 kB)
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Supplemental Material for Zhang et al., 2020

Version 2 2020-01-29, 13:27
Version 1 2019-12-26, 18:50
dataset
posted on 2020-01-29, 13:27 authored by Peichuan ZhangPeichuan Zhang, Yuying Zhai, James Cregg, Kenny Kean-Hooi Ang, Michelle Arkin, Cynthia Kenyon
Revised supplemental text, supplemental figures S1 to S10, and supplemental tables S1 to S9 for manuscript G3/2019/400618

History

Article title

Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules that Affect Aging Pathways and Extend Caenorhabditis elegans’ Lifespan

Manuscript #

G3/2019/400618R1

Article DOI

10.1534/g3.119.400618

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    G3: Genes|Genomes|Genetics

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