# Table S1: AUCs for dosage-response simulations based on plates 2-5. Dosage-response encoded matrix linear models outperform all other methods shown within each plate. These include S scores for data encoded with categorical condition-dosage combinations, for any of the three representations (Cond.-Conc, 1/3 Hits, and 2/3 Hits), as well as S scores for data encoded with just the conditions. Plate 1 Plate 2 Plate 3 Plate 4 Plate 5 Plate 6 MLM Dos. Resp. 0.714 0.707 0.779 0.688 0.736 0.72 Cond.-Conc. 0.612 0.623 0.663 0.591 0.644 0.632 Conditions 0.694 0.683 0.753 0.666 0.713 0.705 1/3 Hits 0.65 0.657 0.713 0.625 0.673 0.683 2/3 Hits 0.612 0.634 0.666 0.588 0.655 0.63