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Supplemental Materials for Lee et al., 2019

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posted on 05.09.2019 by Han Kyu Lee, Sam Widmayer, Min-Nung Huang, David L. Aylor, Douglas A. Marchuk

In common inbred mouse strains, infarct volume after cerebral arterial occlusion is inversely correlated with collateral vessel density, since the collateral circulation provides a compensatory shunt to the ischemic territory. Here we have identified a strain that breaks this inverse correlation. A cross between this (WSB/EiJ) and another strain identified 4 new neuroprotective loci modulating cerebral infarct volume while not affecting collateral vessel density. We surveyed non-synonymous coding SNPs between the strains and also performed RNA sequencing of brain tissue to identify candidate genes. The identification of the genes underlying these neuroprotective loci will provide new understanding of ischemic stroke.

History

Article title

Novel Neuroprotective Loci Modulating Ischemic Stroke Volume in Wild-Derived Inbred Mouse Strains

Manuscript #

GENETICS/2019/302555

Article DOI

10.1534/genetics.119.302555

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