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Supplemental Material for Evans and Andersen, 2020

dataset
posted on 08.05.2020 by Kathryn Evans, Erik Andersen
File S1 contains the results of the original dose response high-throughput fitness assay. File S2 contains the residual phenotypic values for all 159 set 1 RIAILs, 296 set 2 RIAILs, and parent strains (N2 and CB4856) in response to all eight chemotherapeutics. File S3 contains the linkage mapping results for the set 2 RIAILs for all 32 drug-response traits tested in the high-throughput fitness assay. File S4 is a VCF that reports the genotype of ECA1114. File S5 contains the simplified genotype of all the NILs in the study. File S6 contains the raw pruned phenotypes for the NIL dose response with the modified high-throughput fitness assay. File S7 contains the pairwise statistical significance for all strains and high-throughput assays. File S8 contains the microarray expression data for 14,107 probes from Rockman et al. 2010. File S9 contains the linkage mapping results for the expression data obtained with the set 1 RIAILs. File S10 contains the location of each eQTL hotspot and a list of genes with an eQTL in each hotspot. File S11 contains the linkage mapping results from the set 1 RIAILs for all 32 drug-response traits tested in the high-throughput fitness assay. File S12 contains the pairwise mediation estimates for all 32 drug-response traits and all 49 probes. File S13 contains the raw pruned phenotypes for the scb-1 deletion modified high-throughput fitness assay. The datasets and code for generating figures can be found at https://github.com/AndersenLab/scb1_mediation_manuscript. Supplemental materials are available at Figshare.

History

Article title

The Gene scb-1 Underlies Variation in Caenorhabditis elegans Chemotherapeutic Responses

Manuscript #

G3/2020/401310R1

Article DOI

10.1534/g3.120.401310

Licence

Exports