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Supplemental Material for Cao et al., 2021

dataset
posted on 16.03.2021, 16:54 by Jingli Cao, Weiwei Xian, Maierdan Palihati, Yu Zhu, Guoxiang Wang, Yunli Xie, Guomin Zhou, Linya You

Figures include Figure 1-5. Figure 1 showed that Brpf1 knockdown led to a mild reduced trend on the differentiation of MGE-derived GABAergic interneurons into PV+ interneurons. Figure 2 showed that Brpf1 knockdown had no significant effect on the dendritic morphology of MGE-derived GABAergic interneurons. Figure 3 showed that Brpf1 deficiency led to attenuated inhibitory neurotransmission of MGE-derived GABAergic interneurons. Figure 4 showed that Brpf1 deficiency had no effect on the neuronal migration of MGE-derived GABAergic interneurons in vivo. Figure 5 showed that Brpf1 deficiency led to decreased Map2k7 expression in MGE-derived GABAergic interneurons revealed by mRNA-Seq. Supplementary materials include Reagent Table and Table S1. Table S1 contains DESeq2 output and the FPKM values of genes. All reagents and software were listed in the Reagent Table.

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Article title

Deficiency of intellectual disability-related gene Brpf1 reduced inhibitory neurotransmission in MGE-derived GABAergic interneurons