posted on 2019-09-05, 19:36authored byHan Kyu Lee, Sam WidmayerSam Widmayer, Min-Nung Huang, David L. Aylor, Douglas A. Marchuk
In
common inbred mouse strains, infarct volume after cerebral arterial occlusion
is inversely correlated with collateral vessel density, since the collateral
circulation provides a compensatory shunt to the ischemic territory. Here we have
identified a strain that breaks this inverse correlation. A cross between this
(WSB/EiJ) and another strain identified 4 new neuroprotective loci modulating
cerebral infarct volume while not
affecting collateral vessel density. We surveyed non-synonymous coding SNPs
between the strains and also performed RNA sequencing of brain tissue to
identify candidate genes. The identification of the genes underlying these
neuroprotective loci will provide new understanding of ischemic stroke.
History
Article title
Novel Neuroprotective Loci Modulating Ischemic Stroke Volume in Wild-Derived Inbred Mouse Strains