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Supplemental Material for Schlather et al., 2019

Version 2 2019-06-24, 17:07
Version 1 2019-06-24, 17:02
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posted on 2019-06-24, 17:07 authored by Torsten Pook, Martin Schlather, Gustavo de los Campos, Manfred Mayer, Chris Carolin Schoen, Henner Simianer

File S1: Additional method section on setting a target coverage.


File S2: Additional method section on the graphical representation of haplotype blocks.


File S3: Additional method section - toy example for calculation of bEHH.


File S4: Script to simulate a diallel design in MoBPS


Table S1: Proportion of variance explained between the full SNP-dataset (X), a SNP-subset (Xs) and the block dataset (Z). For comparability the number of parameters in Xs and Z were chosen equally using traditionally heritability estimation as in de los Campos (2017).


Table S2: Influence of the window size on the haplotype library for chromosome 1 in the KE DH-lines with a target coverage of 95%.


Table S3: Influence of the weighting of block length (wl) and number of haplotypes (wn) on the haplotype library for chromosome 1 in the KE DH-lines with a target coverage of 95%.


Table S4: Influence of using the extended-block-identification on the haplotype library in dependency of the parameter t of the extended-block-identification-step for chromosome 1 in the KE DH-lines with a target coverage of 95%.


Figure S1: Dataset for the toy example used in File S3.


Figure S2: Comparison of the block structure and a bifurcation plot (Sabeti et al., 2002, Gautier and Vitalis, 2012) according SNP 10,000 on chromosome 1 in the KE DH-lines.


Figure S3: Comparison of the block structure for MCMB=1000 (A), MCMB=5000 (B), MCMB=20,000 (C) for the first 20,000 SNPs of chromosome 1 in the KE DH-lines.




History

Article title

HaploBlocker: Creation of subgroup specific haplotype blocks and libraries

Manuscript #

GENETICS/2019/302283