Version 2 2020-03-11, 14:15Version 2 2020-03-11, 14:15
Version 1 2020-03-11, 14:12Version 1 2020-03-11, 14:12
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posted on 2020-03-11, 14:15authored byDaniel R. McHugh, Elena Koumis, Paul Jacob, Jennifer Goldfarb, Michelle Schlaubitz-Garcia, Safae Bennani, Paul Regan, Prem Patel, Matthew J. Youngman
These data support our functional characterization of DAF-16 during aging in Caenorhabditis elegans. We monitored the survival of daf-16 mutant larvae and adults upon infection with the bacterial pathogen P. aeruginosa to investigate a possible role for DAF-16 in host defense. We also examined age-dependent changes in gene expression, including transcriptional targets of DAF-16, by RNAseq, by qRT-PCR, and by in vivo reporter analysis.
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Article title
DAF-16 and SMK-1 Contribute to Innate Immunity During Adulthood in Caenorhabditis elegans