Supplemental Material for Feofanova et al., 2018

Figure S1 shows proportion of single nucleotide variants by minor allele frequency for sequencing data. Figure S2 contains Manhattan plots and QQ-plots for the statistically significant replicated traits. Figure S3 demonstrates distribution of rare variants in EAs and AAs. Figure S4 pictures predicted levels of <i>FADS1</i> and <i>FADS2</i> in skeletal muscle by rs174564 genotypes in EAs. Table S1 contains basic characteristics of the 102 lipid-related traits. Common variants significantly associated with lipid-related traits in EAs, AAs, or in meta-analysis can be found in Table S2, with sentinel common variant-region pairs significantly associated in meta-analysis available in Table S3. Association of predicted gene transcription levels with lipid-related phenotypes in EAs is presented in Table S4. Table S5 contains Whole Genome T5 results significantly associated in meta-analysis. Rare nonsynonimous exonic variants of <i>SLC10A1</i> – glycocholate are listed in Table S6. Table S7 contains regulatory domain T5 results significantly associated in meta-analysis. Rare variants and conditional analyses for the regulatory element of <i>CYP3A43 </i>for 3 traits are available in Tables S8 and S9, respectively. Table S10 has sliding windows T5 results significantly associated in meta-analysis, with rare variants of the significant and replicated sliding windows listed in Table S11. Table S12 contains variants used for gene transcription levels imputation in EAs.