Supplemental Material for Hamza et al., 2020 Akil Hamza Maureen R.M. Driessen Erik Tammpere Nigel J. O'Neil Philip Hieter 10.25386/genetics.11573229.v1 https://gsajournals.figshare.com/articles/dataset/Supplemental_Material_for_Hamza_et_al_2020/11573229 <p>Figure S1 contains complementation assays for the nonessential CIN genes. Figure S2 contains complementation assays of two-subunit yeast complexes. Figure S3 contains growth curve assays for testing hFEN1 inhibitors in MMS. Figure S4 contains growth curve assays for testing hFEN1 inhibitors in HR-deficient strains. Figure S5 contains growth curve assays assessing overexpression of h<i>FEN1</i> in yeast. Table S1 lists primers used for CRISPR-mediated insertion and deletion. Table S2 lists plasmids and strains used in study. Table S3 lists all candidate complementation pairs tested in study. Table S4 compares our list of complementation pairs to literature sources.</p> 2020-01-14 19:17:33 Human-yeast cross-species complementation chromosome instability chemical inhibitors Fen1 cancer targets Cancer Cell Biology Evolutionary Biology Genetics Molecular Biology